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Columbia University’s Data Science Institute Presents:
DATA SCIENCE DAY

Authors/Collaborators are listed in alphabetical order.



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Wednesday, April 6 • 2:00pm - 4:30pm
Mapping Cells and Their Connections in Networks of the Brain Master Clock [P7]

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Understanding the neural networks associated with specific brain functions is a challenge. The brain’s master clock, located in the suprachiasmatic nucleus (SCN), and made up of ~20,000 “clock cells”, presents an ideal system for exploring the relationship of cellular/molecular events to inter-connections among cells, and how these networks sustain the body’s daily rhythms. At the intracellular level, rhythmicity is produced by feedback loops involving daily rhythms in expression of “clock” genes and associated proteins. To determine whether or not all SCN cells are identical in their intracellular/molecular clocks, we designed programs to assess protein expression levels over days, over time of day, and in location of individual cells within the nucleus, using Mathematica. Our novel approach to analyzing neural networks yields evidence of both regional and cellular specialization of clock protein expression. The findings point to a new mechanism for encoding information in SCN networks.

Demo/Poster Presenter
avatar for Erica Mezias

Erica Mezias

Research Assistant, Cognitive Development Center, Barnard College
Erica Mezias is a senior at Barnard College majoring in Psychology.  She is currently working on a senior thesis in Neuroscience and Behavior in Dr. Rae Silver's Neurobiology lab where she investigates the molecular basis of circadian rhythms using novel computational methods.  Erica has experience running analyses in Wolfram Mathematica to characterize circadian oscillations at the molecular level in brain tissue.
avatar for Malini Riddle

Malini Riddle

Undergraduate Research Assistant, Neuroscience & Behavior, Barnard College
Malini is a junior at Barnard College majoring in cellular neuroscience. She works as a research assistant at Dr. Rae Silver's Neurobiology Lab at Barnard, where she studies circadian rhythms using quantitative computational methods that she helps to develop. Malini has  experience in programming and running analyses using Wolfram Mathematica software to characterize and map circadian oscillations in brain tissue.

Demo/Poster Collaborator
DF

Duncan Foley

Department of Economics, New School for Social Research
JL

Joseph Lesauter

Senior Research Scientist in Psychology, Barnard College
RS

Rae Silver

Helene L. and Mark N. Kaplan Professor of Natural and Physical Sciences, Columbia University

Wednesday April 6, 2016 2:00pm - 4:30pm
Roone Arledge Auditorium Lerner Hall, Columbia University 2920 Broadway, New York, NY 10040

Attendees (1)