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Wednesday, April 6 • 2:00pm - 4:30pm
Real-Time Optical Spectroscopic Monitoring of Permanent Lesion Progression During Cardiac Radiofrequency Ablation [P8]

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Despite considerable advances in guidance of radiofrequency ablation (RFA) therapies for atrial fibrillation, success rates have been hampered by an inability to intraprocedurally characterize the extent of permanent injury. Insufficient lesions can elusively create transient conduction blockages that eventually re-conduct. Prior studies suggest significantly greater met-myoglobin concentrations (ctMmb) in the lesion core than in the healthy myocardium and may serve as a marker for irreversible tissue damage. In this work, we present real-time monitoring of permanent injury through spectroscopic assessment of ctMmb at the catheter tip. A commercial RFA catheter was modified accept illumination and collection fiber pairs to acquire real-time optical measurements throughout RF energy delivery. Dynamic changes in ctMmb were recovered from near-infrared diffuse reflectance spectra using a two-step inversion routine. A robust correlation (r=0.88,P<1e-7) was observed between extracted tissue ctMmb and the extent of tissue injury. These results support the use of spectroscopy-facilitated guidance of RFA procedures.

Demo/Poster Presenter
avatar for Charles C. Marboe, MD

Charles C. Marboe, MD

Professor of Pathology and Cell Biology, College of Physicians and Surgeons
Dr. Charles C. Marboe graduated from the Pennsylvania State University College of Medicine in 1976. He works in New York, NY and specializes in Anatomic Pathology. Dr. Marboe is affiliated with New York Presbyterian Hospital Columbia University Medical Center.
avatar for Christine P. Hendon

Christine P. Hendon

Assistant Professor of Electrical Engineering, Columbia Engineering
Christine Hendon is an assistant professor in the Department of Electrical Engineering.  Her research interests are in developing optical imaging and spectroscopy instruments for applications in cardiac electrophysiology and interventional cardiology. Dr. Hendon received the B.S... Read More →

Rajinder Singh-Moon

PhD Candidate in Electrical Engineering, Columbia Engineering
avatar for Vivek Iyer, MD

Vivek Iyer, MD

Assistant Professor of Medicine, College of Physicians and Surgeons
Vivek Iyer, MD, MSE is a cardiac electrophysiologist, specializing in treating heart rhythm abnormalities. Dr. Iyer is boarded in Internal Medicine, Cardiovascular Disease and Clinical Cardiac Electrophysiology.
avatar for William Whang, MD

William Whang, MD

Associate Professor of Medicine, College of Physicians and Surgeons
avatar for Xinwen Yao

Xinwen Yao

PhD Candidate in Electrical Engineering, Columbia Engineering

Wednesday April 6, 2016 2:00pm - 4:30pm EDT
Roone Arledge Auditorium Lerner Hall, Columbia University 2920 Broadway, New York, NY 10040